EXCEDE for Lactating Dairy Cows: Overview of Research Supporting a 2-Dose Regimen for Treatment of Metritis

etritis is an inflammation of the uterus caused by bacterial infection, and is a common, costly, even life-threatening disease of dairy cows. Clinical metritis most commonly occurs in the first 10 days post-calving, and affected cows may subsequently exhibit poor reproductive performance with irregular estrous cycles, lower conception rates, and greater intervals from calving to pregnancy. Clinical metritis is characterized by fever, fetid vulvar discharge, depression, inappetence, and a uterus with excess fluid and lacking tone. The literature demonstrates that infection of the uterus with Escherichia coli appears to predispose animals for subsequent infection with other bacteria that further contribute to the condition.